Sickle Cell Disease Critique Template

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Sickle Cell Disease Critique Template

Not all-inclusive – if you have another idea, but aren’t sure if it fits under the biotech umbrella, please email me or stop by with a copy of the article. Remember, if it is not on this list, it must be pre-approved.
Articles used for journal critiques must be research articles (clinical trial, case reports or meta-analyses), not review or continuing education articles.

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Note that these topics would also apply for the popular media critiques, and many of the general topics would be good ideas for the fictional critiques (i.e. books/movies such as “Boys from Brazil” and “Jurassic Park” deal with cloning, “Gattaca” deals with genetic engineering and testing).

General topics:

• Biosimilars
• Stem cell research
• Cloning
• Genetically modified food or animals / Biopharming
• Polymerase chain reaction
• Blotting techniques (southern, northern, western)
• Pharmacogenomics
• Biotech techniques as used in forensics / DNA profiling
• Genome editing
• Gene therapy
• RNA interference / RNAi
• Antisense / morpholinos
• Genetic testing
• Neutralizing antibodies as potential Covid treatment; testing methods for such antibodies


Hematopoietic growth factors

• Filgrastim (Neopogen®, Zarxio®)
• Pegfilgrastim (Neulasta®)
• Tbo-filgrastim (Granix®)
• Sargramostim (Leukine®)
• Erythropoietin (Epogen®, Procit®)
• Darbapoetin (Aranesp®)

Cytokines and Antagonists
• Interleukins
 Interleukin-2 (Proleukin®)
 Interleukin-11 (Neumega®)
 Denileukin Difitox (Ontak®)

• Interferons
 Interferon alpha-2a (Roferon®, Pegasys®)
 Interferon alpha-2b (Intron A®, Rebetron®, PEG-Intron®)
 Interferon alfacon-1 (Infergen®)
 Interferon alfa-N3 (Alferon N®)
 Interferon beta-1a (Rebif®, Avonex®)
 Interferon beta-1b (Betaseron®, Extavia®)
 Interferon gamma-2b (Actimmune®)
 Interferon lambda (in development)

• Interleukin / TNF antagonists

 Anakinra (Kineret®)

Becaplermin (Regranex®)

Hormones (derived from biotechnology sources only)
• Glucagon (GlucaGen®, Baqsimi®, Gvoke®)
• Inhaled insulin (Afrezza®)
• Buccal insulin (Oral-lyn®)
• Growth hormone
 Somatrem (Protropin®)
 Somatropin (Humatrope®, Nutropin®, Saizen®, Serostim®)
• Follicle-stimulating hormone
 Follitropin alpha (Gonal-F®)
 Follitropin beta (Follistim®)

Enzymes (Partial list. Only recombinant enzymes are acceptable)
• Alteplase (Activase®)
• Asfotase alfa (Strensig®)
• Avalglucosidase alfa-ngpt (Nexviazyme®)
• C1 esterase inhibitor (Ruconest®)
• Cerliponase alfa (Brineura®)
• Dornase alpha (Pulmozyme®)
• Drotrecogin alpha (Xigris®) – no longer on market
• Elosulfase alfa (Vimizim®)
• Imiglucerase (Cerezyme®)
• Pegaspargase (Oncaspar®)
• Pegloticase (Krystexxa®)
• Pegvaliase-pjpz (Palynziq™)
• Retaplase (Retevase®)
• Sebelipase alfa (Kanuma®)
• Tenecteplase (TNKase®)

Coagulation and anti-coagulation factors
• Antihemophilic Factor / von Willebrand Factor complex (Humate-P®)
• Antihemophilic Factor (recombinant) Fc Fusion Protein1 (Eloctate™)
• Bivalirudin (Angiomax®)
• Desirudin (Ipravask®)
• Eptifibatide (Integrilin®)
• Factor VIIa (NovoSeven®)
• Factor VIII (Advate®, Eloctate®, Helixate®, Kogenate FS®, Novoeight®, Recombinate®, Xyntha®, Nuwiq®)
• Factor IX (Alprolix®, Rixubis®, Benefix®, Ixinity®)
• Lepirudin (Refludan®)
• von Willebrand Factor (Vonvendi®)


Sickle Cell Disease Critique Template

Sickle Cell Disease Critique Template

Monoclonal antibodies and fusion proteins (may include others in development; biosimilar names not included here)

• Abatacept (Orencia®)
• Abciximab (Reopro®)
• Adalimumab (Humira®)
• Ado-trastuzumab emtansine (Kadcyla®)
• Aducanumab (in development)
• Aflibercept (Eylea®)
• Alemtuzumab (Campath-1H®, Lemtrada®)
• Alirocumab (Praluent®)
• Amatuximab – in development
• Amivantamab-vmjw (Rybrevant®)
• Anifrolumab (Saphnelo®)
• Atezolizumab (Tecentriq®)
• Avelumab (Bavencio®)
• Basiliximab (Simulect®)
• Belatacept (Nulojix®)
• Belimumab (Benlysta®)
• Benralizumab (Fasenra®)
• Bevacizumab (Avastin®)
• Bezlotoxumab (Zinplava®)
• Blinitumomab (Blincyto®)
• Brentuximab vedotin (Adcetris®)
• Brodalumab (Siliq®)
• Burosumab-twza (Crysvita®)
• Canakinumab (Ilaris®)
• Caplacizumab-yhdp (Cablivi®)
• Cemiplimab-rwlc (Libtayo®)
• Certolizumab (Cimizia®)
• Cetuximab (Erbitux®)Crizanlizumab-tmca (Adakveo®)
• Daclizumab (Zenapax®, Zinbryta®)
• Daratumumab (Darzalex®)
• Denosumab (Prolia®, Xgeva®)
• Dinutuxumab (Unituxin®)
• Dostarlimab (Jemperli®)
• Dupilumab (Dupixent®)
• Eculizumab (Soliris®)
• Elotuzumab (Empliciti®)
• Emapalumab-lzsg (Gamifant®)
• Emicizumab-kxwh (Hemlibra®)
• Epratuzumab – in development
• Erenumab-aooe (Aimovig®)
• Eternacept (Enbrel®)
• Evolocumab (Repatha®)
• Fremanezumab-vfrm (Ajovy®)
• Galcanezumab-gnlm (Emgality®)
• Golimumab (Simponi®)
• Guselkumab (Tremfya®)
• Ibalizumab-uiyk (Trogarzo®)
• Ibritumomab tiuxetan (Zevulin Y-90®)
• Idarucizumab (Praxbind®)
• Infliximab (Remicade®)
• Inotuzumab ozogamicin (Besponsa®)
• Ipilumomab (Yervoy®)
• Ixekizumab (Taltz®)
• Lanadelumab-flyo (Takhzyro®)
• Luspatercept-aamt (Reblozyl®)
• Mepolizumab (Nucala®)
• Mogamulizumab-kpkc (Poteligeo®)
• Moxetumomab pasudotox-tdfk (Lumoxiti®)
• Natalizumab (Tysabri®)
• Necitumumab (Portrazza®)
• Nivolumab (Opdivo®)
• Obiltoxaximab (Anthim®)
• Obinutuzumab (Gazyva®)
• Ocrelizumab (Ocrevus®)
• Ofatumumab (Arzerra®)
• Olaratumab (Lartruvo®)
• Omalizumab (Xolair®)
• Palivizumab (Synagis®)
• Panitumumab (Vectibix®)
• Pembrolizumab (Keytruda®)
• Pertuzumab (Perjeta®)
• Polatuzumab vedotin-piiq (Polivy®)
• Ramucirumab (Cyramza®)
• Ranibizumab (Lucentis®, Susvimo®)
• Ravulizumab-cwvz (Ultomiris®)
• Raxibacumab
• Reslizumab (Cinqair®)
• Rilonacept (Arcalyst®)
• Risankizumab-rzaa (Skyrizi®)
• Rituximab (Rituxan®)
• Romosozumab-aqqg (Evenity®)
• Sarilumab (Kevzara®)
• Secukinumab (Cosentyx®)
• Siltuximab (Sylvant®)
• Tildrakizumab-asmn (Ilumya®)
• Tocilizumab (Actevma®)
• Trastuzumab (Herceptin®)
• Ustekinumab (Stelara®)
• Vedolizumab (Entyvio®)
• Ziv-aflibercept (Zaltrap®)
• Zmapp (trio of monoclonals for ebola) – in development



Antisense oligonucleotides (topic in general, or one of products below):

• Affinitak
• Alicaforsen (Camligo®)
• Eteplirsen (Exondys 51)
• Fomiversen (Vitravene®)
• Mipomersen (Kynamro®)
• Nusinersen (Spinraza®)
• Oblimersen (Genasense®)

RNA interference (topic in general, or product below):
• Patisiran (Onpattro®)

Gene therapies (topic in general, or one of products below):
• Axicabtagene ciloleucel (Yescarta®)
• Talimogene laherparepvec (Imlygic®)
• Voretigene neparvovec-rzyl (Luxturna®)

Other products produced by genetic engineering, recombinant or gene-editing methods
• Sipuleucel-T (Provenge®) – recombinant cancer vaccine
• Tisagenlecleucel (Kymriah®)




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